From Toronto:

Get on Gardiner Expy W from Bay St.

Take Queen Elizabeth Way

QEW to Ontario St/Regional Rd 42 in St. Catharines

Take the Regional Rd 42/Ontario St exit from Queen Elizabeth Way

Follow Ontario St/Regional Rd 42 to your destination

Holiday Inn & Suites St. Catharines Conf Ctr, an IHG Hotel

327 Ontario St, St. Catharines, ON L2R 5L3

From London:

Take ON-401 E

ON-403 E to Hamilton

Take Lincoln Alexander Parkway to Red Hill Valley Expressway to

Queen Elizabeth Way to St. Catharines

Take the Regional Rd 42/Ontario St exit from Queen Elizabeth Way

Follow Ontario St/Regional Rd 42 to your destination

Holiday Inn & Suites St. Catharines Conf Ctr, an IHG Hotel

327 Ontario St, St. Catharines, ON L2R 5L3